Publikationen

  • Abdelmageed N, Morad S, Elghoneimy A, Syrovets T, Simmet Th, El-Zorba H, El-Banna H, Cabot M, Abdel-Aziz M (2017) Oleanolic acid methyl ester, a novel cytotoxic mitocan, induces cell cycle arrest and ROS-Mediated cell death in castration-resistant prostate cancer PC-3 cells. Biomed Pharmacother. 96:417-25
  • Liu Y, Steinestel K, Rouhi A, Armacki M, Diepold K, Chiosis G, Simmet Th, Seufferlein T, Azoitei N (2017) STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1α/VEGF signaling pathway. Oncotarget 8:77474-88
  • Schmidt C, Loos C, Jin L, Schmiech M, Schmidt CQ, El Gaafary M, Syrovets T, Simmet Th (2017) Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo. Oncotarget 8:55147-161
  • Claus S, Meinhardt K, Aumüller T, Puscalau-Girtua I, Lindera J, Haupt C, Walther P, Syrovets T, Simmet Th, Fändrich M (2017) Cellular mechanism of fibril formation from serum amyloid A1 protein. EMBO Rep 18:1352-66
  • Eder S, Arndt A, Lamkowski A, Daskalaki W, Rump A, Priller M, Genze F, Wardelmann E, Port M, Steinestel K (2017) Baseline MAPK signaling activity confers intrinsic radioresistance to KRAS-mutant colorectal carcinoma cells by rapid upregulation of heterogeneous nuclear ribonucleoprotein K (hnRNP K). Cancer Lett. 385:160-167
  • Zuo Z, Syrovets T, Wu Y, Hafner S, Vernikouskaya I, Liu W, Ma G, Weil T, Simmet T, Rasche V (2017) The CAM cancer xenograft as a model for initial evaluation of MR labelled compounds. Sci Rep 7:46690
  • Claus S, Puscalau-Girtu I, Walther P, Syrovets T, Simmet Th, Haupt C, Fändrich M (2017) Cell-to-cell transfer of SAA1 proteinn in a cell culture model of systemic AA amyloidosis. Sci Rep 7:45683
  • Harder MJ, Kuhn N, Schrezenmeier H, Höchsmann B, von Zabern I, Weinstock C, Simmet Th, Ricklin D, Lambris JD, Skerra A, Anliker M, Schmidt CQ (2017) Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation. Blood 129:970-980
  • Breitfeld J, Scholl C, Steffens M, Brandenburg K, Probst-Schendzielorz K, Efimkina O, Gurwitz D, Ising M, Holsboer F, Lucae S, Stingl JC (2016) Proliferation rates and gene expression profiles in human lymphoblastoid cell lines from patients with depression characterized in response to antidepressant drug therapy. Transl Psychiatry 6:e950
  • Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Köhntop R, Lin Q, Holzmann KG, Seufferlein T, Wagner M, Liebau S, Hermann PC, Kleger A, Müller M (2016) Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Stem Cell Res 17: 367-78
  • Mayer B, Keller F, Syrovets T, Wittau M (2016) Estimation of half-life periods in nonlinear data with fractional polynomials. Stat Methods Med Res 25:1791-1803
  • Huber-Lang M, Gebhard F, Schmidt CQ, Palmer A, Denk S, Wiegner R (2016) Complement therapeutic strategies in trauma, hemorrhagic shock and systemic inflammation - closing Pandora's box? Semin Immunol 28:278-84
  • Stamm TJ, Rampp C, Wiethoff K, Stingl J, Mössner R, O Malley G, Ricken R, Seemüller F, Keck M, Fischer R, Gaebel W, Maier W, Möller HJ, Bauer M, Adli M (2016) The FKBP5 polymorphism rs1360780 influences the effect of an algorithm-based antidepressant treatment and is associated with remission in patients with major depression. J Psychopharmacol 30:40-7
  • Schmidt CQ, Lambris JD, Ricklin D (2016) Protection of host cells by complement regulators. Immunol Rev 274:152:71
  • Steffens M, Paul T, Hichert V, Scholl C, von Mallek D, Stelzer C, Sörgel E, Reiser B, Schumann C, Boeck S, Heinemann V, Kächele V, Seufferlein T, Stingl J (2016) Dosing to rash?--The role of erlotinib metabolic ratio from patient serum in the search of predictive biomarkers for EGFR inhibitor-mediated skin rash. Eur J Cancer 55:131-9
  • Hafner S, Haubensak S, Paul T, Zolk O (2016) How to individualize drug therapy based on pharmacogenetic information? A systematic review of published guidelines. Dtsch Med Wochenschr 141: e183-202
  • Kuhn N, Schmidt CQ, Schlapschy M, Skerra A (2016) PASylated coversin, a C5-specific complement inhibitor with extendes pharmacokinetics, shows enhanced anti-hemolytic activity in vitro. Bioconjug Chem 27:2359-71
  • Ezzat S, El Gaafary M, El Sayed A, Sabry O, Ali Z, Hafner S, Schmiech M, Jin L, Syrovets T, Simmet Th (2016) The cardenolide glycoside acovenoside a affords protective activity in doxorubicin-induced cardiotoxicity in mice. J Pharmacol Exp Ther 358:262-70
  • Krutzke L, Prill JM, Engler T, Schmidt CQ, Xu Z, Byrnes AP, Simmet Th, Kreppel F (2016) Substitution of blood coagulation factor X-binding to Ad5 by position-specific PEGylation: Preventing vector clearance and preserving infectivity. J Control Release 235:379-92
  • Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, Handl L, Heinrich L, Loos C, Schmidt M, Syrovets T, Simmet Th, Westermark GT, Horn U, Schmidt V, Walther P, Fändrich M (2016) Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. Proc Natl Acad Sci USA 113:5604-09
  • Weber ML, Schneider DT, Offenmüller S, Kaatsch P, Einsiedel HG, Benesch M, Claviez A, Ebinger M, Kramm C, Kratz C, Lawlor J, Leuschner I, Merkel S, Metzler M, Nustede R, Petsch S, Seeger KH, Schlegel PG, Suttorp M, Zolk O, Brecht IB (2016) Pedriatric colorectal carcinoma is associated with excellent outcome in the context of cancer predisposition syndromes. Pediatr Blood Cancer 63:611-7
  • Abderrazak A, El Hadri K, Bosc E, Blondeau B, Slimane MN, Büchele B, Simmet Th, Couchie D, Rouis M (2016) Inhibition of the inflammasome NLRP3 by arglabin attenuates inflammation, protects pancreatic β-cells from apoptosis, and prevents type 2 diabetes mellitus development in ApoE2.Ki mice on a chronic high-fat diet. J Pharmacol Exper Ther 357:487-94
  • Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisam T, Gilson PR, Barlow PN, Crabbs BS, Cowman AE, Tham WH (2016) Recruitment of factor H as a novel complement evasion strategy for blood-stage plasmodium falciparum infection. J Immunol 196:1239-48
  • Hulea L, Markovic Z, Topisirovic I, Simmet Th, Trajkovic V (2016) Biomedical potential of mTOR modulation by nanoparticles. Trends Biotechnol 34:349-53
  • Beck S, Simmet Th, Müller I, Lang F, Gawaz M (2016) Gremlin-1 C-terminus regulates function of macrophage migration inhibitory factor (MIF). Cell Physiol Biochem 38:801-08
  • Schmidt CQ, Harder M, Nichols E, Hebecker M, Anliker M, Höchsmann B, Simmet Th, Csincsi A, Uzonyi B, Pappworth I, Ricklin D, Lambris J, Schrezenmeier H, Jozsi M, Marchbank K (2016) Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients. Immunobiology 221:503-11
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
  • Fuchs A, Syrovets T, Haas K, Loos C, Musyanovych A, Mailänder V, Landfester K, Simmet Th (2016) Carboxyl- and amino-functionalized polystyrene nanoparticles differentially affect the polarization profile of M1 and M2 macrophage subsets. Biomaterials 85:78-87
  • Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, Simmet Th, Seufferlein T (2016) PKM2 promotes tumor angiogenesis by regulating HIF-1a through NF-?B activation. Mol Cancer 15:3
  • Harder M, Anliker M, Höchsmann B, Simmet Th, Huber-Lang M, Schrezenmeier H, Ricklin D, Lambris J, Barlow P, Schmidt CQ (2016) Comparative analysis of novel complement-targeted inhibitors, miniFH, and the natural regulators factor H and factor H-like protein 1 reveal functional determinants of complement regulation. J Immunol 196:866-76
  • Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T16, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R (2015) The international SSRI pharmacogenomics consortium (ISPC): a genome-wide association study of antidepressant treatment response. Transl Psychiatry 5:e553
  • Hasheminasab SM, Tzvetkov MV, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Steffens M, Scholl C, Hichert V, Seufferlein T, Brockmöller J, Stingl JC (2015) High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors. Pharmacogenomics 16:1605-19
  • Hichert V, Steffens M, Paul T, Scholl C, Parmar S, Rüdiger S, Schumann C, Seufferlein T, Stingl JC (2015) Gene regulatory biomarker identification for skin toxicities induced by EGFR inhibitor treatment. Int J Clin Pharmacol Ther 53:1056-8
  • Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J, Partch , Restagno G, Rujescu D, Schnack C, Shaw CE, Shaw PJ, Tumani H, Tysnes OB, Valladares O, Silani V, van den Berg LH, van Rheenen W, Veldink JH, Lindenberger U, Steinhagen-Thiessen E, SLAGEN Consortium, Teipel S, Perneczky R, Hakonarson H, Hampel H, von Arnim CA, Olsen JH, Van Deerlin VM, Al-Chalabi A, Toft M, Ritz B, Bertram L (2015) The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement 11:1407-16
  • Klenk J, Kerse N, Rapp K, Nikolaus T, Becker C, Rothenbacher D, Peter R, Denkinger MD; ActiFE Study Group (2015) Physical activity and different concepts of fall risk estimation in older people - results of the ActiFE-Ulm study. PLoS One 10:e0129098
  • Nagel G, Herbolsheimer F, Riepe M, Nikolaus T, Denkinger M, Peter R, Weinmayr G, Rothenbacher D, Koenig W, Ludolph AC, von Arnim CA; ActiFE Study group (2015) Serum vitamin D concentrations and cognitive function in a population-based study among older adults in South Germany. J Alzheimers Dis 45:1119-26
  • Fabbri C, Crisafulli C, Gurwitz D, Stingl J, Calati R, Albani D, Forloni G, Calabrò M, Martines R, Kasper S, Zohar J, Juven-Wetzler A, Souery D, Montgomery S, Mendlewicz J, Girolamo GD, Serretti A (2015) Neuronal cell adhesion genes and antidepressant response in three independent samples. Pharmacogenomics J 15:538-48
  • Probst-Schendzielorz K, Scholl K, Efimkina O, Ersfeld E, Viviani R, Serretti A, Fabbri C, Gurwitz D, Lucae S, Ising M, Paul A, Lehmann ML, Steffens M, Crisafulli C, Calabrio M, Holsboer F, Stingl JC (2015) CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich antidepressant response signature (MARS) study. Pharmacogenomics 16:689-701
  • Probst-Schendzielorz K, Viviani R, Stingl JC (2015) Effect of cytochrome P450 polymorphism on the action and metabolism of selective serotonin reuptake inhibitors. Expert Opin Drug Metab Toxicol 11:1219-32
  • Lim N, Harder M, Kennedy A, Lin C, Weir C, Cowman A, Call M, Schmidt CQ, Tham W (2015) Characterization of inhibitors and monoclonal antibodies that modulate the interaction between Plasmodium falciparum adhesion PfRh4 with its erythrocyte receptor complement receptor 1. J Biol Chem 290:25307-21
  • Abderrazak A, Couchie D, Darweesh Mahmood DF, Elhage R, Vindis C, Laffargue M, Matéo V, Büchele B, Ayala MR, El Gaafary ME, Syrovets Th, Slimane MN, Friguet B, Fulop T, Simmet Th, Hadri KE, Rouis M (2015) Response to letter regarding article, "Anti-inflammatory and antiatherogenic effects of the inflammasome NLRP3 inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet". Circulation 132:e250-1
  • Wu Y, Ermakova A, Liu W, Pramanik G, Vu TM, Kurz A, McGuiness L, Naydenov B, Hafner S, Reuter R, Wrachtrup J, Isoya J, Förtsch C, Barth H, Simmet Th, Jelezko F, Weil T (2015) Programmable biopolymers for advancing biomedical applications of fluorescent nanodiamonds. Adv Funct Mater 25:6576-85
  • Hafner S, Zolk K, Radaelli F, Otte J, Rabenstein T, Zolk O (2015) Water infusion versus air insufflation for colonoscopy. Cochrane Database Syst Rev 5:CD009863
  • Hacker K, Maas R, Kornhuber J, Fromm MF, Zolk O (2015) Substrate-dependent inhibition of the human organic cation transporter OCT2: a comparison of metformin with experimental substrates. PLoS One 10:e0136451
  • Lin Z, Schmidt CQ, Koutsogiannaki S, Ricci P, Risitano AM, Lambris JD, Ricklin D (2015) Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria. Blood 126:891-4
  • Abderrazak A, Couchie D, Faieeq D, Mahmood D, Elhage R, Vindis C, Laffargue M, Mateo V, Büchele B, Ayala M, El Gaafary M, Syrovets T, Slimane M, Friguet B, Fulop T, Simmet Th, El Hadri K, Rouis M (2015) Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation 131:1061-70
  • Schmidt CQ, Kennedy AT, Tham WH (2015) More than just immune evasion: hijacking complement by Plasmodium falciparum. J Immunol 67:71-84
  • Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, Rodewald K, Zolk O, Schwantes U, Siegmund W, Keiser M (2015) Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm 12:171-8
  • Müller F, Pontones C, Renner B, Mieth M, Hoier E, Auge D, Maas R, Zolk O, Fromm M (2015) N1-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction. Eur J Clin Pharmacol 71:85-94
  • Zuo Z, Syrovets T, Genze F, Abaei A, Ma G, Simmet Th, Rasche V (2015) High-resolution MRI analysis of breast cancer xenograft on the chick chorioallantoic membrane. NMR Biomed 28:440-47
  • Lucas T, Benihoud K, Vigant F, Schmidt CQ, Bachem M, Simmet Th, Kochanek S (2015) Hexon modification to improve the activity of oncolytic adenovirus vectors against neoplastic and stromal cells in pancreatic cancer. PLoS One 10:e0117254
  • Brüstle I, Simmet Th, Nienhaus GU, Landfester K, Mailänder V (2015) Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation. Beilstein J Nanotechnol. 6:383-95
  • Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet Th, Rouis M (2015) NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol 4:e296-307
  • Nonnenmacher L, Westhoff M, Fulda S, Karpel-Massler G, Halatsch M, Engelke J, Simmet Th, Corbacioglu S, Debatin K (2015) Rist: A potent new combination therapy for glioblastoma. Int J Cancer 136:e173-87
  • Elgaafary M, Büchele B, Syrovets T, Agnolet S, Schneider B, Schmidt CQ, Simmet Th (2015) An a-acetoxy-tirucallic acid isomer inhibits Akt/mTOR signaling and induces oxidative stress in prostate cancer cells. J Pharmacol Exp Ther 352:33-42
  • Kraeenbring J, Penza T, Gutmann J, Muehlich S, Zolk O, Wojnowski L, Maas R, Engelhardt S, Sarikas (2014) Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology. PLoS One 9:e106930
  • Cárdenas-Morales L, Grön G, Sim EJ, Stingl JC, Kammer T (2014) Neural activation in humans during a simple motor task differs between BDNF polymorphisms. PLoS One 9:e96722
  • Clark SJ, Schmidt CQ, White AM, Hakobyan S, Morgan BP, Bishop PN (2014) Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. J Immunol 193:4962-70
  • Rondonotti E, Zolk O, Amato A, Paggi S, Baccarin A, Spinzi G, Radaelli F (2014) The impact of hyoscine-N-butylbromide on adenoma detection during colonoscopy: meta-analysis of randomized, controlled studies. Gastrointest Endosc 80:1103-12
  • Viviani R, Lehmann ML, Stingl JC (2014) Use of magnetic resonance imaging in pharmacogenomics. Br J Clin Pharmacol 77:684-94
  • Kumar ST, Meinhardt J, Fuch AK, Aumüller T, Leppert J, Büchele B, Knüpfer U, Ramachandran R, Yadav JK, Prell E, Morgado I, Ohlenschläger O, Horn U, Simmet Th, Görlach M, Fändrich M (2014) Structure and biomedical applications of amyloid oligomer nanoparticles. ACS Nano 8:11042-52
  • Loos C, Syrovets T, Msyanovych A, Mailänder V, Landfester K, Nienhaus GU, Simmet Th (2014) Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions. Beilstein J Nanotechnol 5:2403-12
  • Shang L, Nienhaus K, Jiang X, Yang L, Landfester K, Mailänder V, Simmet Th, Nienhaus GU (2014) Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects. Beilstein J Nanotechnol 5:2388-97
  • Hagn M, Blackwell SE, Beyer T, Ebel V, Fabricius D, Lindner S, Stilgenbauer S, Simmet Th, Tam C, Neeson P, Trapani JA, Schrezenmeier H, Weiner GJ, Jahrsdörfer B (2014) B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and interleukin 21. Int Immunol 26:383-395
  • Wittig R, Rosenholm JM, von Haartman E, Hemming J, Genze F, Bergman L, Simmet Th, Lindén M, Sahlgren C (2014) Active targeting of mesoporous silica drug carriers enhances g-secretase inhibitor efficiency in an in vivo model of breast cancer. Nanomedicine (Lond) 9:971-987
  • Offenmüller S, Ravindranath Y, Goyette G, Kanakapalli D, Miller KS, Brecht IB, Zolk O (2014) Focused screening of a panel of cancer-related genetic polymorphisms reveals new susceptibility loci for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer 61:1411-15
  • Paul T, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Steffens M, Scholl C, Hichert V, Seufferlein T, Stingl JC (2014) Cytokine regulation by epidermal growth factor receptor inhibitors and epidermal growth factor receptor inhibitor associated skin toxicity in cancer patients. Eur J Cancer 50:1855-63
  • Liu M, Wu Q, Chen P, Büchele B, Bian M, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet Th, Shen J (2014) A boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-?B signaling in mice. PLoS One 9:e100129
  • Kittel A, Müller F, König J, Mieth M, Sticht H, Zolk O, Kralj A, Heinrich MR, Fromm MF, Maas R (2014) Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and b-aminoisobutyrate metabolism in healthy volunteers. PLoS One 9:e88544
  • Zablotskii V, Syrovets T, Schmidt Z, Dejneka A, Simmet Th (2014) Modulation of monocytic leukemia cell function and survival by high gradient magnetic fields and mathematical modeling studies. Biomaterials 35:3164-71
  • Stingl JC, Bartels H, Viviani R, Lehmann ML, Brockmöller J (2014) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacol Ther 141:92-116
  • Sangkuhl K, Stingl JC, Turpeinen M, Altman R, Klein TE (2014) PharmGKB summary: venlafaxine pathway. Pharmacogenet Genomics 24:62-72
  • Park HJ, Guariento M, Maciejewski M, Hauhart R, Tham WH, Cowman AF, Schmidt CQ, Mertens HD, Liszweski MK, Hourcade DE, Barlow PN, Atkinson JP (2014) Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor. J Biol Chem 389:450-63
  • Loos C, Syrovets T, Musyanovych A, Mailänder V, Landfester K, Simmet Th (2014) Amino-functionalized nanoparticles as inhibitors of mTOR and inducers of cell cycle arrest in leukemia cells. Biomaterials 35:1944-53
  • Krauss J, Gratzl C, Sturm V, Müller C, Staudacher V, Schmidt CQ, Bracher F (2013) Synthesis and biological evaluation of novel alkyl-imidazolyl carbinols and their esters: potent antimycotics. Sci Pharm 81:641-50
  • Stamm TJ, Stingl J, Wiethoff K, Ricken R, Heinz A, Bauer M, O’Malley G, Adli M (2013) Depression with psychotic features is influenced by the polymorphism of the serotonin transporter gene. J Affect Disord 2:605-10
  • Meineke I, Willnow C, Stingl J, Brockmöller J (2013) Routine micromethod for the determination of vitamin K1 in human plasma. Ther Drug Monit 6:859-62
  • Fabricius D, Nußbaum B, Busch D, Panitz V, Mandel B, Vollmer A, Westhoff MA, Kaltenmeier C, Lunov O, Tron K, Nienhaus GU, Jahrsdörfer B, Debatin KM (2013) Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells. J Immunol 3:1144-53
  • Westhoff MA, Zhou S, Nonnenmacher L, Karpel-Massler G, Jennewein C, Schneider M, Halatsch ME, Carragher NO, Baumann B, Krause A, Simmet Th, Bachem MG, Wirtz CR, Debatin KM (2013) Inhibition of NF-?B signaling ablates the invasive phenotype of glioblastoma. Mol Cancer Res 12:1611-23
  • Strobel J, Mueller F, Zolk O, Endress B, Koenig J, Fromm M, Maas R (2013) Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1). Amino Acids 45:989-1002
  • Schmidt CQ, Bai H, Lin Z, Risitano A, Barlow P, Ricklin D, Lambris J (2013) Rational engineering of a minimized immune inhibitor with unique triple-targeting properties. J Immunol 11:5712-21
  • Parmar S, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kächele V, Seeringer A, Paul T, Seufferlein T, Stingl JC (2013) Pharmacogenetic predictors for EGFR-inhibitor-associated skin toxicity. Pharmacogenomics J 13:181-88
  • Stingl JC, Brockmöller J, Viviani R (2013) Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function. Mol Psychiatry 18:273-87
  • Stingl JC, Bartels H, Viviani R, Lehmann ML- Brockmöller J (2013) Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review. Pharmacol Ther S0163-7258
  • Abler B, Kumpfmüller D, Grön G, Walter M, Stingl JC, Seeringer A (2013) Neural correlates of erotic stimulation under different levels of female sexual hormones. PLoS One. 8:e54447
  • Hicks JK, Swen JJ, Thorn CF, Sangkuhl K, Kharasch ED, Ellingrod VL, Skaar TC, Müller DJ, Gaedigk A, Stingl JC (2013) Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressant. Clin Pharmacol Ther 93:402-8
  • Abduljalil K, Lazar S, Natanzon M, WuW, zadoyan G, Steffens B, Kohl V, Mörike K, Tomalik-Scharte D, Stingl JC, Schwab M, Harenberg J, Gleiter C, Fuhr U (2013) Quantifying the effect of covariates on concentrations and effects of steady-state phenprocoumon using a population pharmacokinetic/pharmacodynamics model. Clin Pharmacokinet 52:359-71
  • Verhoef TI, Redekop WK, Veenstra DL, Thariani R, Beltman PA, van Schie RM, de Boer A, Mailtland-van der Zee AH; EU-PACT Group (2013) Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation. Pharmacogenomics 14:869-83
  • Stamm Tj, Stingl JC, Wiethoff K, Ricken R, Heinz Am, Bauer M, O’Malley G, Adli M (2013) Depression with psychotic features is influenced by the polymorphism of the serotonin transporter gene. J Affect Disord 151:605-10
  • Müller I, Schönberger T, Schneider M, Borst O, Ziegler M, Seizer P, Leder C, Müller K, Lang M, Appenzeller F, Lunov O, Büchele B, Fahrleitner M, Olbricht M, Langer H, Geisler T, Lang F, Chatterjee M, de Boer JF, Tietge UJ, Bernhagen J, Simmet Th, Gawaz M (2013) Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- mice. J Biol Chem 288:31635-45
  • Schmitz B, Vischer P, Brand E, Schmidt-Petersen K, Korb-Pap A, Guske K, Nedele J, Schelleckes M, Hillen J, Rötrige A, Simmet Th, Paul M, Cambien F, Brand SM (2013) Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation in vitro. Altherosclerosis 230:185-90
  • Mahmood DF, Abderrazak A, El Hadri K, Simmet Th, Rouis M (2013) The thioredoxin system as a therapeutic target in human health and disease. Antioxid Redox Signal 19:1266-03
  • Li Q, Laumonnier Y, Syrovets T, Simmet Th (2013) Recruitment of CCR6-expressing Th17 cells by CCL20 secreted from plasmin-stimulated macrophages. Acta Biochim Biophys Sin 45:593-600
  • Li Q, Syrovets S, Simmet Th, Ding J, Xu J, Chen W, Zhu D, Gao P (2013) Plasmin induces intercellular adhesion molecule 1 expression in human endothelial cells via nuclear factor-?B/mitogen-activated protein kinases-dependent pathways. Exp Biol Med (Maywood) 238:176-86
  • Lindner S, Dahlke K, Sontheimer K, Hagn M, Kaltenmeier C, Barth T, Beyer T, Reister F, Fabricius D, Lotfi R, Lunov O, Nienhaus GU, Simmet Th, Kreienberg R, Möller P, Schrezenmeier H, Jahrsdörfer B (2013) Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res 73:2468-79
  • Mahmood D, Abderrazak A, Couchie D, Lunov O, Diderot V, Syrovets T, Slimane M, Gosselet F, Simmet Th, Rouis M, El Hadri, K (2013) Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis. J Cell Physiol 228:1577-83
  • Liu M, Chen P, Büchele B, Dong S, Huang D, Ren C, Zhang Y, Hou X, Simmet Th, Shen J (2013) A boswellic acid-containing extract attenuates hepatic granuloma in C57BL/6 mice infected with Schistosoma japonicum. Parasitol Res 3:1105-11
  • Volamanova M, Meier C, Shaytan AK, Vas V, Bertonicini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet Th, Bohne J. Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J (2013) Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol 8:130-36
  • Morad Samy AF, Schmid M, Büchele B, Siehl H-U, El Gafaary M, Lunov O, Syrovets T, Simmet Th (2013) A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells. Mol Pharmacol 83:531-41
  • Eichhorn T, Winter D, Büchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet Th, Granzin J, Efferth T (2013) Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum. Biochem Pharmacol 85:38-45
  • Tetteh-Quarcoo P, Schmidt CQ, Tham WH, Hauhart R, Mertens H, Rowe A, Atkinson J, Cowman A, Rowe JA, Barlow P (2012) Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PloS One 7:e34820
  • Morgan H, Mertens H, Guariento M, Schmidt CQ, Soares D, Svergun D, Herbert A, Barlow P, Hannan J (2012) Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). PloS One 7:e32187
  • Goodship T, Pappworth I, Toth T, Denton M, Houlberg K, McCormick F, Warland D, Moore I, Hunze EM, Staniforth S, Hayes C, Cavalcante D, Kavanagh D, Strain L, Herbert A, Schmidt CQ, Barlow P, Harris C, Marchbank K (2012) Factor H autoantibodies in membranoproliferative glomerulonephritis. Mol Immunol 52:200-6
  • Makou E, Mertens H, Maciejewski M, Soares D, Matis I, Schmidt CQ, Herbert A, Svergun D, Barlow P (2012) Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H. J Mol Biol 5:295-12
  • Li X, Syrovets T, Simmet Th (2012) The serine protease plasmin triggers expression of the CC-chemokine ligand 20 in dendritic cells via Akt/NF-?B-dependent pathways. J Biomedi Biotechnol 10:1155-64
  • Ohayon MM, Stingl JC (2012) Prevalence and comorbidity of chronic pain in the German general population. J Psychiatr Res 4:444-50
  • Viviani R, Abler B, Seeringer A, Stingl JC (2012) Effect of paroxetine and bupropion on human resting brain perfusion: an arterial spin labelling study. Neuroimage 4:773-79
  • Verhoef TI, Redekop WK, Van Schie RM, Bayat S, Daly AK, Geitona M, Haschke-Becher E, Hughes DA, Kamali F, Levin LA, Manolopoulos VG, Pirmohamed M, Siebert U, Stingl JC, Wadelius M, De Boer A, Maitland-van der Zee AH, The EU-PACT group (2012) Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. Pharmacogenomics 12:1405-17
  • Fuerst D, Parmar S, Schumann C, Rüdiger S, Boeck S, Heinemann V, Kaechele V, Stiebel K, Paul T, Seufferlein T, Mytilineos J, Stingl JC (2012) HLA polymorphisms influence the development of skin rash arising from treatment with EGF receptor inhibitors. Pharmacogenomics 10:1469-76
  • Oved K , Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, Rehavi M, Stingl JC, Gurwitz D (2012) Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers. Pharmacogenomics 13:1129-39
  • Syrovets T, Lunov O, Simmet Th (2012) Plasmin as a proinflammatory cell activator. J Leukoc Biol 92:509-19
  • Ramchoun M, Harnafi H, Alem C, Büchele B, Simmet Th, Rouis M, Atmani F, Amrani S (2012) Hypolipidemic and antioxidant effect of polyphenol-rich extracts from Moroccan thyme varieties. e-SPEN Journal 7:e119-e124
  • El Hadri K, Mahmood D, Couchie D, Jguirim-Souissi I, Genze F, Diderot V, Syrovets T, Lunov O, Simmet Th, Rouis M (2012) Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis. Arterioscler Thromb Vasc Biol. 32:1445-52
  • Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, Von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, Von Arnim CA (2012) Genetic variants in PSEN2 and correlation to CSF ß-amyloid42 levels in AD. Neurobiol Aging 33:201.e9-201.e18
  • Koelch M, Pfalzer AK, Kliegl K, Rothenhöfer S, Ludolph AG, Fegert JM, Burger R, Mehler-Wex C, Stingl J, Taurines R, Egberts K, Gerlach M (2012) Therapeutic drug monitoring of children and adolescents treated with fluoxetine. Pharmacopsychiatry 2:72-6
  • Hagn M, Sontheimer K, Dahlke K, Brueggemann S, Kaltenmeier C, Beyer T, Hofmann S, Lunov O, Barth TF, Fabricius D, Tron K, Nienhaus GU, Simmet T, Schrezenmeier H, Jahrsdörfer B (2012) Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help. Immunol Cell Biol 4:457-67
  • Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schönberger T, Jürgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet Th, Gawaz M (2012) The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice. Circulation 125:685-96
  • Popovic M, Smiljanic K, Dobutovic B, Syrovets T, Simmet Th, Isenovic E (2012) Human cytomegalovirus infection and atherothrombosis. J Thromb Thrombolysis 33:160-172
  • Stingl JC, Esslinger C, Tost H, Bilek E, Kirsch P, Ohmle B, Viviani R, Walter H, Rietschel M, Meyer-Lindenberg A (2012) Genetic variation in CYP2D6 impacts neural activation during cognitive tasks in humans. Neuroimage 59:2818-2823
  • Popovic M, Smiljanic K, Dobutovic B, Syrovets T, Simmet Th, Isenovic R. (2012) Thrombin and vascular inflammation. Moll Cell Biochem 359:301-13
  • Kirchheiner J, Seeringer A, Godoy AL, Ohmle B, Maier C, Beschoner P, Sim EJ (2011) CYP2D6 in the brain: genotype effects on resting brain perfusion. Mol Psychiatry 16:333-41
  • Schjeide BM, Schnack C, Lambert JC, Lill CM, Kirchheiner J, Tumani H, Otto M, Tanzi R, Lehrach H, Amouyel P, Arnim CAF, Bertram L (2011) The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry 68:207-13
  • Schie van RM, Wessels JA, Cessie le S, Boer de A, Schalekamp T, Meer van der FJ, Verhoef TI, Meegen van E, Rosendaal FR, Maitland-van der Zee AH, EU-PACT-Study Group (2011) Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data. Eur Heart J. 32:1909-17
  • Avery PJ, Jorgensen A, Hamberg AK, Wadelius M, Pirmohamed M, Kamali F, EU-PACT-Study Group (2011) A proposal for an individualized pharmacogenetics-based warfarin initiation dose regimen for patients commencing anticoagulation therapy. Clin Pharmacol Ther 90:701-06
  • Lunov O, Syrovets T, Loos C, Nienhaus GU, Mailänder V, Landfester K, Rouis M, Simmet Th (2011) Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages. ACS Nano 5: 9648-57
  • Parmar S, Stingl JC, Huber-Wechselberger A, Kainz A, Renner W, Langsenlehner U, Krippl P, Brockmöller J, Haschke-Becher E (2011) Impact of UGT2B7 His 268Tyr polymorphism on the outcome of adjuvant epirubicin treatment in breast cancer. Breast Cancer Res 13:57
  • Tomalik-Scharte D, Fuhr U, Hellmich M, Frank D, Doroshyenko O, Jetter A, Stingl JC (2011) Effect of the CYPC8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide. Drug Metab Dispos 39:927-32
  • Parmar S, Seeringer A, Denich D, Gärtner F, Pitterle K, Syrovets T, Ohmle B, Stingl JC (2011) Variability in transport and biotransformation of cytarabine is associated with its toxicity in peripheral blood mononuclear cells. Pharmacogenomics 12:503-14
  • Abler B, Seeringer A, Hartmann A, Grön G, Metzger C, Walter M, Stingl JC (2011) Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled FMRI study on healthy males under subchronic paroxetine and bupropion. Neuropsychopharmacology 36:1837-47
  • Tzvetkov MV, Saadatmand AR, Lötsch J, Tegeder I, Stingl JC, Brockmöller J (2011) Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. Clin Pharmacol Ther 90:143-50
  • Van Schie RM, Wessels JA, le Cessie S, de Boer A, Schalekamp T, Van der Meer FJ, Verhoef TI, Van Meegen E, Rosendaal FR, Maitland-van der Zee AH. For the EU-PACT Study Group (2011) Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data. Eur Heart J 32:1909-17
  • Stingl JC, Ettrich T, Muche R, Wiedom M, Brockmöller J, Seeringer A, Seufferlein T (2011) Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC Caner 11:360
  • Hiemke C, Baumann P, Bergemann N, Conca A, Dietmaier O, Egberts K, Fric M, Gerlach M, Greiner C, Gründer G, Haen E, Havemann-Reinecke U, Jaquenoud Sirot E, Kirchherr H, Laux G, Lutz UC, Messer T, Müller MJ, Pfuhlmann B, Rambeck B, Riederer P, Schoppek B, Stingl J, Uhr M, Ulrich S, Waschgler R, Zernig G (2011) AGNP consensus guidelines for therapeutic drug monitoring in Psychiatry. Pharmacopsychiatry 44:195-235
  • Li Q, Laumonnier Y, Syrovets T, Simmet Th (2011) Yeast two-hybrid screening of proteins interacting with plasmin receptor subunit: C-terminal fragment of annexin A2. Acta Pharmacol Sin 32:1411-8
  • Zablotskii V, Lunov O, Dejneka A, Jastrabik L, Polyakova T, Syrovets T, Simmet Th (2011) Nanomechanics of magnetically driven cellular endocytosis. Appl Phys Lett 99:183701
  • Morad SA, Schmidt C, Büchele B, Schneider B, Syrovets T, Simmet Th (2011) (8R)-3b,8-Dihydroxypolypoda-13E,17E,21-triene induces cell cycle arrest and apoptosis in treatment-resistant prostate cancer cells. J Nat Prod 74:1731-36
  • Mahmood DF, Jguirim-Souissi I, El-Hadri K, Blondeau N, Diderot V, Amrani S, Slimane MN, Syrovets T, Simmet Th, Rouis M (2011) Peroxisome proliferator-activated receptor g induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L. J Biol Chem 286:28858-66
  • Lunov O, Zablotskii V, Syrovets T, Röcker C, Tron K, Nienhaus GU, Simmet Th (2011) Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages. Biomaterials 32:547-55
  • Zeibig S, Li Z, Wagner S, Holthoff HP, Ungerer M, Bültmann A, Uhland K, Vogelmann J, Simmet Th, Gawaz M, Münch G (2011) Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis. Circ Res 108:695-703
  • Lunov O, Syrovets T, Loos C, Beil J, Delacher M, Tron K, Nienhaus GU, Musyanovych A, Mailänder V, Landfester K, Simmet Th (2011) Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line. ACS Nano 5:1657-69
  • Stingl JC, Viviani R (2011) CYP2D6 in the brain: Impact on suicidality. Clin Pharmacol Ther 89:352-3
  • Morag A, Pasmanik-Chor M, Oron-Karni V, Rehavi M, Stingl JC, Gurwitz D (2011) Genome-wide expression profiling of human lymphoblastoid cell lines identifies CHL1 as a putative SSRI antidepressant response biomarker. Pharmacogenomics 12:171-84
  • Stingl JC, Brockmöller J (2011) Why, when, and how should pharmacogenetics be applied in clinical studies?: current and future approaches to study designs. Clin Pharmacol Ther 89:198-209
  • Holstein A, Hahn M, Patzer O, Seeringer A, Kovacs P, Stingl JC (2011) Impact of clinical factors and CYP2C9 variants for the risk of severe sulfonylurea-induced hypoglycemia. Pharmacogenetics 67:471-6
  • Stingl JC, Parmar S, Huber-Wechselberger A, Kainz A, Renner W, Seeringer A, Brockmöller J, Langsenlehner U, Krippl P, Haschke-Becher E (2010) Impact of CYP2D6*4 genotype on progression free survival in tamoxifen breast cancer treatment. Curr Med Res Opin 26:2535-42
  • Lebedeva E, Stingl J, Thal D, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe M, Högel J, Ludolph A, von Arnim CA (2010) Genetic variants in PSEN2 and correlation to CSF b-amyloid42 levels in AD. Neurobiol Ageing 33:201.e9-201.e18
  • Viviani R, Lo H, Sim EJ, Beschoner P, Stingl JC, Horn AB, (2010) The neural substrate of positive bias in spontaneous emotional processing. PLoS One 5: e15454
  • Denkinger MD, Franke S, Rapp K, Weinmayr G, Duran-Tauleria E, Nikolaus T, Peter R, ActiFE Ulm Study Group (2010) Accelerometer-based physical activity in a large observational cohort-study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study. BMC Geriatr 10:50
  • Tomalik-Scharte D, Maiter D, Kirchheiner J, Ivison HE, Fuhr U, Arlt W (2010) Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency. Eur J Endocrinol 163:919-24
  • Abduljalil K, Frank D, Gaedigk A, Klaassen T, Tomalik-Scharte D, Jetter A, Jaehde U, Kirchheiner J, Fuhr U (2010) Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromenthorphan. Clin Pharmacol Ther 88:643-51
  • Seeringer A, Parmar S, Fischer A, Altissimo B, Zondler L, Lebedeva E, Pitterle K, Roots I, Kirchheiner J (2010) Genetic variants of the insulin receptor substrate-1 are influencing the therapeutic efficacy of oral antidiabetics. Diabetes Obes Metab 12:1106-12
  • Jetter A, Fätkenheuer G, Frank D, Klaassen T, Seeringer A, Doroshyenko O, Kirchheiner J, Hein W, Schömig E, Fuhr U, Wyen C (2010) Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients. Antivir Therm 15:975-83
  • Hasche-Becher, E, Kirchheiner J, Trummer O, Grünbacher G, Kainz A, Boehm BO, März W, Renner W (2010) Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort. Pharmacogenomics 11:1359-65
  • Lunov O, Zablotskii V, Pastor J, Landazabal J, Gomez-Polo C, Syrovets T, Simmet Th (2010) Thermal destruction on the nanoscale: cell membrane hyperthermia with functionalized magnetic nanoparticles. AIP Conf Proc 1311:288-92
  • Lunov O, Zablotskii V, Syrovets T, Röcker C, Tron K, Nienhaus GU, Simmet Th (2010) Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages Biomaterials 32:547-55
  • Lunov O, Syrovets T, Röcker C, Tron K, Nienhaus GU, Rasche V, Mailänder V, Landfester K, Simmet Th (2010) Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes. Biomaterials 31:9015-22
  • Qun L, Fang K, Weiwei Z, Laumonnier Y, Syrovets T, Simmet Th, Wang H (2010) A role for the annexin A2 amino-terminal peptide in the plasmin-induced activation of human peripheral monocytes. Mol Immunol 47:2405-10
  • Daub K, Siegel-Axel D, Schönberger T, Leder C, Seizer P, Müller K, Schaller M, Penz S, Menzel D, Büchele B, Bültmann A, Münch G, Lindemann S, Simmet Th, Gawaz M (2010) Inhibition of foam cell formation using a soluble CD68-Fc fusion protein. J Mol Med 88:909-20
  • Popovic M, Paskaš S, Zivkovic M, Burysek L, Laumonnier Y (2010) Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors. J Thromb Thrombolysis 30:164-71
  • Kirchheiner J, Seeringer A, Godoy AL, Ohmle B, Maier C, Beschoner P, Sim EJ, Viviani R (2010) CYP2D6 in the brain: genotype effects on resting brain perfusion. Mol Psychiatry 16:333-41
  • Verhoef TI, Redekop WK, Darba J, Geitona M, Hughes DA, Siebert U, de Boer A, Maitland-van der Zee AH, Barallon R, Briz M, Daly A, Haschke-Becher E, Kamali F, Kirchheiner J, Manolopoulos VG, Pirmohamed M, Rosendaal FR, van Schie RM, Wadelius M; EU-PACT Group (2010) A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. Pharmacogenomics 11:989-1002
  • Hagn M, Ebel V, Sontheimer K, Schwesinger E, Lunov O, Beyer T, Fabricius D, Barth TF, Viardot A, Stilgenbauer S, Hepp J, Scharffetter-Kochanek K, Simmet Th, Jahrsdörfer B (2010) CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B. Eur J Immunol 40:2060-69
  • Morag A, Kirchheiner J, Rehavi M, Gurwitz D (2010) Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways. Pharmacogenomics 11:327-40
  • Ceschi A, Curkovic I, Kirchheiner J, Kullak-Ublick GA, Jetter A (2010) Interactions with antiretroviral drugs. Internist 51:94-9
  • Lunov O, Syrovets T, Büchele B, Jiang X, Röcker C, Tron K, Nienhaus GU, Walther P, Mailänder V, Landfester K, Simmet Th (2010) The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages. Biomaterials 31:5063-71
  • Uttner I, Kirchheiner J, Tumani H, Mottaghy FM, Lebedeva E, Ozer E, Ludolph AC, Huber R, von Arnim CA (2010) A novel presenilin1 mutation (Q223R) associated with early onset Alzheimer's disease, dysarthria and spastic paraparesis and decreased Abeta levels in CSF. Eur J Neurol 17:631-3
  • Büchele B, Zugmaier W, Lunov O, Syrovets T, Merfort I, Simmet Th (2010) Surface plasmon resonance analysis of NF-kB protein interactions with the sesquiterpene lactone helenalin. Anal Biochem 401:30-7
  • Kirchheiner J, Seeringer A, Viviani R (2010) Pharmacogenetics in psychiatry - a useful clinical tool or wishful thinking for the future? Curr Pharm Des 16:136-44
  • Viviani R, Sim EJ, Lo H, Beschoner P, Osterfeld N, Maier C, Seeringer A, Godoy AL, Rosa A, Comas D, Kirchheiner J (2010) Baseline brain perfusion and the serotonin transporter promoter polymorphism. Biol Psychiatry 67: 317-22
  • Li X, Syrovets T, Genze F, Pitterle K, Oberhuber A, Orend KH, Simmet Th (2010) Plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response. Arterioscler Thromb Vasc Biol 30:582-90
  • Estrada AC, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana-Pfeifer J, Schmidt T, Morad SA, Simmet Th (2010) Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Mol Pharmacol 77:378-87
  • Jahrsdörfer B, Vollmer A, Blackwell SE, Maier J, Sontheimer K, Beyer T, Mandel B, Lunov O, Tron K, Nienhaus GU, Simmet Th, Debatin KM, Weiner GJ, Fabricius D (2010) Granzyme B produced by human plasmacytoid dendritic cells suppresses T cell expansion. Blood 115:1156-65
  • Zablotskii V, Lunov O, Gómez-Polo C (2010) Model for hyperthermia with arrays of magnetic nanoparticles: spatial and time temperature distributions in tumor. J Nanosci Nanotechnol 10:1-6
  • Fabricius D, Neubauer M, Mandel B, Schütz C, Viardot A, Vollmer A, Jahrsdörfer B, Debatin KM (2010) Prostaglandin E2 inhibits IFN-a secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement. J Immunol 184:677-84
  • van Schie RM, Wadelius MI, Kamali F, Daly AK, Manolopoulos VG, de Boer A, Barallon R, Verhoef TI, Kirchheiner J, Haschke-Becher E, Briz M, Rosendaal FR, Redekop WK, Pirmohamed M, van der Zee AH (2009) Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. Pharmacogenomics 10:1687-95
  • Haack S, Seeringer A, Thürmann PA, Becker T, Kirchheiner J (2009) Sex-specific differences in side effects of psychotropic drugs: genes or gender? Pharmacogenomics 10:1511-26
  • Wang H, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet Th (2009) Targeting NF-kB with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis. J Immunol 183:4755-63
  • Muschler E, Lal J, Jetter A, Rattay A, Zanger U, Zadoyan G, Fuhr U, Kirchheiner J (2009) The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro. Basic Clin Pharmacol Toxicol 105:374-9
  • Hagn M, Schwesinger E, Ebel V, Sontheimer K, Maier J, Beyer T, Syrovets T, Laumonnier Y, Fabricius D, Simmet Th, Jahrsdörfer B (2009) Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J Immunol 183:1838-45
  • He YJ, Zhang W, Chen Y, Guo D, Tu JH, Xu LY, Tan ZR, Chen BL, Li Z, Zhou G, Yu BN, Kirchheiner J, Zhou HH (2009) Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta 405:49-52
  • Rodríguez-Antona C, Gurwitz D, de Leon J, Llerena A, Kirchheiner J, de Mesa EG, Ibarreta D (2009) CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies. Pharmacogenomics 10:685-99
  • Vormfelde S, Brockmöller J, Bauer S, Herchenhein P, Kuon J, Meineke I, Roots I, Kirchheiner J (2009) Relative impact of genotype and enzyme induction on the metabolic capacity of CYP2C9 in healthy volunteers. Clin Pharmacol Ther 86:54-61
  • Mehler-Wex C, Kölch M, Kirchheiner J, Antony G, Fegert JM, Gerlach M (2009) Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychpharmacotherapy. Child Adolesc Psychiatry Ment Health 3:14
  • Kirchheiner J, Rodríguez-Antona C (2009) Cytochrome P450 2D6 genotyping: potential role in improving treatment outcomes in psychiatric disorders. CNS Drugs 23:181-91
  • Leandro-García LJ, Leskelä S, Montero-Conde C, Landa I, López-Jimenez E, Letón R, Seeringer A, Kirchheiner J, Cascón A, Robledo M, Rodríguez-Antona C (2009) Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis. Anal Biochem 389:74-6
  • Doroshyenko O, Fuhr U, Kunz D, Frank D, Kinzig M, Jetter A, Reith Y, Lazar A, Taubert D, Kirchheiner J, Baum M, Eisenbrand G, Berger FI, Bertow D, Berkessel A, Sörgel F, Schömig E, Tomalik-Scharte D (2009) In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity. Cancer Epidemiol Biomarkers Prev 18:433-43
  • Zablotskii V, Lunov O, Gómez-Polo C (2009) Magnetic heating by tunable arrays of nanoparticles in cancer therapy. Acta Phys Pol A 115:413-417
  • Seizer P, Borst O, Langer HF, Bültmann A, Münch G, Herouy Y, Stellos K, Krämer B, Bigalke B, Büchele B, Bachem MG, Vestweber D, Simmet Th, Gawaz M, May AE (2009) EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost 101:682-6
  • Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M, Bhanot U, Hasel C, Möller P, Gschwend JE, Simmet Th, Debatin KM, Fulda S (2009) Small molecule XIAP inhibitors enhance trail-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. Cancer Res 69:2425-34
  • Kirchheiner J, Glatt S, Fuhr U, Klotz U, Meineke I, Seufferlein T, Brockmöller J (2009) Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH. Eur J Clin Pharmacol 65:19-31
  • Seeringer A, Kirchheiner J (2008) Pharmacogenetics-guided dose modifications of antidepressants. Clin Lab Med 28:619-26
  • Billiet L, Furman C, Cuaz-Pérolin C, Paumelle R, Raymondjean M, Simmet Th, Rouis M (2008) Thioredoxin-1 and its natural inhibitor, vitamin D³ up-regulated protein 1, are differentially regulated by PPARa in human macrophages. J Mol Biol 384:564-76
  • Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M, Gschwend JE, Simmet Th, Debatin KM, Fulda S (2008) Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Cancer Res 68:7956-65
  • Stehle S, Kirchheiner J, Lazar A, Fuhr U (2008) Pharmacogenetics of oral anticoagulants: A basis for dose Individualization. Clin Pharmacokinet 47:565-94
  • Li X, Syrovets T, Paskas S, Laumonnier Y, Simmet Th (2008) Mature dendritic cells express functional thrombin receptors triggering chemotaxis and CCL18/pulmonary and activation-regulated chemokine induction. J Immunol 181:1215-23
  • Jahrsdörfer B, Weiner GJ (2008) Short telomeres in B-CLL: the chicken or the egg? Blood 111:5756-7
  • Tomalik-Scharte D, Doroshyenko O, Kirchheiner J, Jetter A, Lazar A, Klaassen T, Frank D, Wyen C, Fätkenheuer G, Fuhr U (2008) No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolam. Eur J Clin Pharmacol 64:1033-5
  • Seeringer A, Kirchheiner J (2008) CYP2D6-, CYP2C9- and CYP2C19-based dose adjustments: When do they make sense? Internist 49:877-83
  • Seeringer A, Brockmöller J, Bauer S, Kirchheiner J (2008) Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate. Eur J Clin Pharmacol 64:883-8
  • Tzvetkov MV, Brockmöller J, Roots I, Kirchheiner J (2008) Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment. Pharmacogenet Genomics 18:495-506
  • He Y, Zhang W, Tu J, Kirchheiner J, Chen Y, Guo D, Li Q, Li Z, Chen H, Hu D, Wang D, Zhou H (2008) Hepatic nuclear factor 1a inhibitor ursodeoxycholic acid (UDCA) influences pharmacokinetics of the OATP1B1 substrate rosuvastatin and bilirubin. Drug Metab Dispos 36:1453-6
  • Kirchheiner J, Lorch R, Lebedeva E, Seeringer A, Roots I, Sasse J, Brockmöller J (2008) Genetic variants in FKBP5 affecting response to antidepressant drug treatment. Pharmacogenomics 9:841-6
  • Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet Th (2008) Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol 84:215-23
  • Tomalik-Scharte D, Lazar A, Fuhr U, Kirchheiner J (2008) The clinical role of genetic polymorphisms in drug-metabolizing enzymes. Pharmacogenomics J 8:4-15
  • Mehler-Wex C, Romanos M, Kirchheiner J, Schulze UM (2008) Atypical antipsychotics in severe anorexia nervosa in children and adolescents - review and case reports. Eur Eat Disord Rev 16:100-8.
  • Klaassen T, Jetter A, Tomalik-Scharte D, Kasel D, Kirchheiner J, Jaehde U, Fuhr U (2008) Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol 64:387-98
  • Wyen C, Fuhr U, Frank D, Aarnoutse R, Klaassen T, Lazar A, Seeringer A, Doroshyenko O, Kirchheiner J, Abdulrazik F, Schmeisser N, Lehmann C, Hein W, Schömig E, Burger D, Fätkenheuer G, Jetter A (2008) Effect of an antiretroviral regimen containing Ritonavir boosted Lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. Clin Pharmacol Ther 84:75-82
  • Kirchheiner J (2008) CYP2D6 phenotype prediction from genotype: which system is the best? Clin Pharmacol Ther 83:225-7
  • Kirchheiner J, Keulen JT, Bauer S, Roots I, Brockmöller J (2008) Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol. J Clin Psychopharmacol 28:78-83
  • Kirchheiner J, Meineke I, Fuhr U, Rodríguez-Antona C, Lebedeva E, Brockmöller J (2008) Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids. Pharmacogenomics 9:277-88
  • He YJ, Brockmöller J, Schmidt H, Roots I, Kirchheiner J (2008) CYP2D6 ultrarapid metabolism and morphine/codeine ratios in blood: Was it codeine or heroin? J Anal Toxicol 32:178-82
  • Stamm TJ, Adli M, Kirchheiner J, Smolka MN, Kaiser R, Tremblay PB, Bauer M (2008) Serotonin transporter gene and response to lithium augmentation in depression. Psychiatr Genet 18:92-7
  • Clarisse Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet Th, Rouis M (2008) Antiinflammatory and antiatherogenic effects of the NF-kB inhibitor acetyl-11-keto-b-boswellic acid in LPS-challenged ApoE-/- mice. Arterioscler Thromb Vasc Biol 28:272-7
  • Jahrsdörfer B, Blackwell S, Weiner G (2007) The effects of CpG ODN on CLL proliferation, apoptosis or phenotype could have an impact on its clinical utility. Leukemia 21:2354-5
  • Swen JJ, Huizinga TW, Gelderblom H, de Vries EG, Assendelft WJ, Kirchheiner J, Guchelaar HJ (2007) Translating pharmacogenomics: challenges on the road to the clinic. PLoS Med 4:e209
  • Adli M, Hollinde DL, Stamm T, Wiethoff K, Tsahuridu M, Kirchheiner J, Heinz A, Bauer M (2007) Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-b-50T/C single nucleotide polymorphism. Biol Psychiatry 62:1295-302
  • Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, Heinz A, Walther DJ, Priller J (2007) Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry 62:1288-94
  • Kirchheiner J, Schmidt H, Tzvetkov M, Keulen JT, Lötsch J, Roots I, Brockmöller J (2007) Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J 7:257-65
  • Maitland-van der Zee AH, Aitchison K, Kirchheiner J (2007) Workshop outcomes report: Initiatives to establish a European Network of pharmacogenetics/genomics and progress. Eur J Pharm Sci 31:151-5
  • Vormfelde SV, Schirmer M, Toliat MR, Meineke I, Kirchheiner J, Nürnberg P, Brockmöller J (2007) Genetic variation at the CYP2C locus and its association with torasemide biotransformation. Pharmacogenomics 7:200-11
  • Brockmöller J, Meineke I, Kirchheiner J (2007) Pharmacokinetics of mirtazapine: enantioselective effects of the CYP2D6 ultra rapid metabolizer genotype and correlation with adverse effects. Clin Pharmacol Ther 81:699-707
  • Kirchheiner J, Nickchen K, Sasse J, Bauer M, Roots I, Brockmöller J (2007) A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment. Pharmacogenomics J 7:48-55
  • Li Q, Laumonnier Y, Syrovets T, Simmet Th (2007) Plasmin triggers cytokine induction in human monocyte-derived macrophages. Arterioscler Thromb Vasc Biol 27:1383-9
  • Fuhr U, Jetter A, Kirchheiner J (2007) Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach. Clin Pharmacol Ther 81:270-83
  • Kirchheiner J, Seeringer A (2007) Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes. Biochim Biophys Acta 1170:489-94
  • Osswald E, Johne A, Laschinski G, Arjomand-Nahad F, Malzahn U, Kirchheiner J, Gerloff T, Meisel C, Mrozikiewicz PM, Chernov J, Roots I, Köpke K (2007) Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers. Eur J Clin Pharmacol 63:9-16
  • Roots I, Laschinski G, Arjomand-Nahad F, Kirchheiner J, Schwarz D, Brockmöller J, Cascorbi I, Gerloff T (2007) Genotype and phenotype relationship in drug metabolism. Ernst Schering Res Found Workshop 59:81-100
  • Kuefer R, Genze F, Zugmaier W, Hautmann RE, Rinnab L, Gschwend JE, Angelmaier M, Estrada A, Büchele B (2007) Antagonistic effects of sodium butyrate and N-(4-hydroxyphenyl)-retinamide on prostate cancer. Neoplasia 9:246-53
  • Unger MM, Wahl J, Ushmorov A, Büchele B, Simmet Th, Debatin KM, Beltinger C (2007) Enriching suicide gene bearing tumor cells for an increased bystander effect. Cancer Gene Ther 14:30-8
  • Kirchheiner J, Thomas S, Bauer S, Tomalik-Scharte D, Hering U, Doroshyenko O, Jetter A, Stehle S, Tsahuridu M, Meineke I, Brockmöller J, Fuhr U (2006) Pharmacokinetics and pharmacodynamics of rosiglitazone in relation to CYP2C8 genotype. Clin Pharmacol Ther 80:657-67
  • Kim MJ, Nafziger AN, Kashuba AD, Kirchheiner J, Bauer S, Gaedigk A, Bertino JS Jr (2006) Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin. Eur J Clin Pharmacol 62:431-6
  • Zhang C, Carl TF, Trudeau ED, Simmet Th, Klymkowsky MW (2006) An NF-kB and slug regulatory loop active in early vertebrate mesoderm. PLoS ONE 1:e106
  • Meineke I, Steinmetz H, Kirchheiner J, Brockmöller J (2006) Therapeutic drug monitoring of mirtazapine, desmethylmirtazapine, 8-hydroxymirtazapine, and mirtazapine-N-oxide by enantioselective HPLC with fluorescence detection. Ther Drug Monit 28:760-5
  • Büchele B, Zugmaier W, Syrovets T, Paetz C, Schneider B, Simmet Th (2006) Supporting Information. Characterization of 3a-acetyl-11-keto-b-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo. Planta Med 72:e332-e337
  • Büchele B, Zugmaier W, Syrovets T, Paetz C, Schneider B, Simmet Th (2006) Characterization of 3a-acetyl-11-keto-a-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo. Planta Med 72:1285-9
  • Heller T, Kirchheiner J, Armstrong VW, Luthe H, Tzvetkov M, Brockmöller J, Oellerich M (2006) AmpliChip CYP450 GeneChip: a new gene chip that allows rapid and accurate CYP2D6 genotyping. Ther Drug Monit 28:673-7
  • Kirchheiner J, Seeringer A, Brockmöller J (2006) State of the art of pharmacogenetic diagnostics in drug therapy. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 49:995-1003
  • Kirchheiner J, Lang U, Stamm T, Sander T, Gallinat J (2006) Association of CYP2D6 genotypes and personality traits in healthy individuals. J Clin Psychopharmacol 26:440-2
  • Kirchheiner J, Gründemann D, Schömig E (2006) Contribution of allelic variations in transporters to the phenotype of drug response. J Psychopharm 20:27-32
  • Laumonnier Y, Syrovets T, Burysek L, Simmet Th (2006) Identification of the annexin A2 heterotetramer as a receptor for the plasmin-induced signaling in human peripheral monocytes. Blood 107:3342-49
  • Seeling W, Kneer L, Büchele B, Gschwend JE, Maier L, Nett C, Simmet Th, Steffen P, Schneider M, Rockemann M (2006) D9-Tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain. Anaesthesist 55:361-400
  • Büchele B, Zugmaier W, Genze F, Simmet Th (2005) High-performance liquid chromatographic determination of acetyl-11-keto-b-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci 829:144-8
  • Mo X, Kowenz-Leutz E, Laumonnier Y, Xu H, Leutz A (2005) Histone H3 positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev 19:2447-57
  • Sterk V, Büchele B, Simmet Th (2005) Gleichzeitige Nahrungsaufnahme steigert die Bioverfügbarkeit weihrauchhaltiger Phytopharmaka. Z Phytotherapie 26:174-80
  • Michel MC, König G, Mohr K, Simmet Th (2005) Editorial guidelines for manuscripts on the pharmacology of plant extracts. Naunyn-Schmiedeberg’s Arch Pharmacol 371:349-50
  • Syrovets T, Gschwend JE, Büchele B, Laumonnier Y, Zugmaier W, Genze F, Simmet Th (2005) Inhibition of IkB kinase activity by acetyl-boswellic acids triggers apoptosis in androgen-independent prostate cancer in vitro and in vivo. J Biol Chem 280:6170-80
  • Syrovets T, Büchele B, Krauß C, Laumonnier Y, Simmet Th (2005) Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-a induction in monocytes by direct interaction with IkB kinases. J Immunol 174:498-506
  • Sterk V, Büchele B, Simmet Th (2004) Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers. Planta Med 70:1155-60
  • Wenk J, Schuller J, Hinrichs C, Syrovets T, Azotei N, Podda M, Wlaschek M, Brenneisen P, Schneider LA, Sabiwalsky A, Peters T, Sulyok S, Disssemond J, Schauen M, Krieg T, Simmet Th, Scharffetter-Kochanek K (2004) Overexpression of phospholipid hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA-induced expression of interstitial collagenase/matrix-metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkB activation and interleukin-6 release. J Biol Chem 279:45634-42
  • Büchele B, Zugmaier W, Simmet Th (2004) Bio-Analytik: HPLC-Photodioden-Array-Methode zur Bestimmung von ?9-Tetrahydrocannabinol in Plasma; Elimination von Stör-Peaks durch gezielte Verwendung der Referenzwellenlänge. GIT Labor-Fachzeitschrift 48:838-40
  • Syrovets T, Simmet Th (2004) Novel aspects and new roles for the serine protease plasmin. Cell Mol Life Sci 61:873-85
  • Büchele B, Zugmaier W, Simmet Th (2004) Phytopharmaka. Analytik von pentazyklischen Triterpenen aus Weihrauchharz, Weihrauchharz-Extrakt Kapseln und H15 Tabletten. GIT Labor-Fachzeitschrift 48:123-7
  • Buryskova M, Pospisek M, Grothey A, Simmet Th, Burysek L (2004) Intracellular interleukin-1a functionally interacts with histone acetyltransferase complexes. J Biol Chem 279:4017-29
  • Herrmann SM, Adler YD, Schmidt-Petersen K, Nicaud V, Morrison C, Paul M, Zouboulis CC (2003) The concomitance of multiple epidermal cysts, osteomas and thyroid gland nodule is not diagnostic for Gardner syndrome in the absence of intestinal polyposis clinical and genetic report. Brit J Dermatol 149:877-83
  • Büchele B, Simmet Th (2003) Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection. J Chromatogr B 795:355-62
  • Brand E, Wang JG, Herrmann SM, Staessen JA (2003) An epidemiological study of blood pressure and metabolic phenotypes in relation to the Gb3 C825T polymorphism. J Hypertension 21:729-37
  • Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T, Simmet Th (2003) Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102:2645-52
  • Belsner K, Büchele B, Werz U, Simmet Th (2003) Structural analysis of 3-a-acetyl-20(29)-lupene-24-carboxylic acid, a novel pentacyclic triterpene isolated from the gum resin of Boswellia serrata, by NMR spectroscopy. Magn Reson Chem 41:629-32
  • Herrmann SM, Wang JG, Staessen JA, Kertmen E, Schmidt-Petersen K, Zidek W, Paul M, Brand E (2003) Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio. J Mol Med 81:327-32
  • Büchele B, Zugmaier W, Simmet Th (2003) Analysis of pentacyclic triterpenic acids from frankincense gum resins and related phytopharmaceuticals by high-performance liquid chromatography. Identification of lupeolic acid, a novel pentacyclic triterpene. J Chromatogr B 791:21-30
  • Funke-Kaiser H, Reichenberger F, Köpke K, Herrmann SM, Pfeifer J, Orzechowski HD, Zidek W, Paul M, Brand E (2003) Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation. Hum Mol Genet 12:423-33
  • Smola SF, Rettenberger G, Simmet Th, Burysek L (2003) Comparison of sample collection methods for the PCR detection of oral anaerobic pathogens. Lett Appl Microbiol 36:101-5
  • Belsner K, Büchele B, Werz U, Syrovets T, Simmet Th (2003) Structural analysis of pentacyclic triterpenes from the gum resin of Boswellia serrata by NMR spectroscopy. Magn Reson Chem 41:115-22
  • Burysek L, Syrovets T, Simmet Th (2002) The serine protease plasmin triggers expressison of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways. J Biol Chem 277:33509-17
  • Syrovets T, Schüle A, Jendrach M, Büchele B, Simmet Th (2002) Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity. Thromb Haemost 88:274-81
  • Burysek L, Pitha PM (2001) Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double stranded RNA-activated protein kinase. J Virol 75:2345-52
  • Syrovets T, Jendrach M, Rohwedder A, Schüle A, Simmet Th (2001) Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKb-mediated NF-kB activation. Blood 97:3941-50
  • Weber CK, Slupsky JR, Kalmes HA, Rapp UR (2001) Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res 61:3595-98
  • Ameri A, Simmet Th (2000) Effects of 2-arachidonylglycerol, an endogenous cannabinoid, on neuronal activity in rat hippocampal slices. Naunyn-Schmiedeberg’s Arch Pharmacol 361:265-72
  • Syrovets T, Büchele B, Gedig E, Slupsky JR, Simmet Th (2000) Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIa. Mol Pharmacol 58:71-81
  • Ameri A, Simmet Th (1999) Antagonism of the aconitine-induced inexcitability by the structurally related Aconitum alkaloids, lappaconitine and ajacine. Brain Res 842:332-41
  • Kogel B, Schneider J, Gleitz J, Wilffert B, Peters T (1999) Effects of AL 107, a novel semisynthetic cardiac glycoside, on the cardiovascular system in anaesthetized beagle dogs with pentobarbital-induced cardiac insufficiency. Drug Res 49:679-84
  • Ameri A, Simmet Th (1999) Interaction of the structurally related aconitum alkaloids, aconitine and 6-benzoylheteratisine, in the rat hippocampus. Eur J Pharmacol 386:187-94
  • Ameri A, Wilhelm A, Simmet Th (1999) Effects of the endogenous cannabinoid, anandamide, on neuronal activity in rat hippocampal slices. Br J Pharmacol 126:1831-9
  • Ameri A, Zimmermann T, Simmet Th (1999) Frequency- and structure-dependent inhibition of normal and epileptiform activity by 6-benzoyldeltamine in rat hippocampal slices. Eur J Pharmacol 369:279-88
  • Hoernlein RF, Orlikowsky Th, Zehrer C, Niethammer D, Sailer ER, Simmet Th, Dannecker GE, Ammon HPT (1999) Acetyl-11-keto-b-boswellic acid (AKBA) induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I. J Pharmacol Exp Ther 288:613-9
  • Ameri A (1999) Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol, 125:461-8
  • Slupsky JR, Quitterer U, Weber CK, Gierschik P, Lohse MJ, Rapp UR (1999) Binding of Gbg subunits to cRaf1 downregulates G-protein-coupled receptor signalling. Curr Biol 9:971-4 
  • Ameri A (1999) The effects of cannabinoids on the brain. Progr Neurobiol. 58:315-48
  • Gläßgen WE, Rose A, Madlung J, Koch W, Gleitz J, Seitz HU (1998) Regulation of enzymes involved in anthocyanin biosynthesis in carrot cell cultures in response to treatment with ultraviolet light and fungal elicitors. Planta 204:490-8
  • Gutser UT, Friese J, Heubach JF, Matthiesen T, Selve N, Wilffert B, Gleitz J (1998), Mode of antinociceptive and toxic action of alkaloids of Aconitum spec. Naunyn-Schmiedeberg’s Arch Pharmacol 357:39-48
  • Ameri A (1998) Effects of the Aconitum alkaloid mesaconitine in rat hippocampal slices and the involvement of a- and b-adrenoceptors. Br J Pharmacol 123:243-50
  • Ameri A (1998) Inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices by the Aconitum alkaloid mesaconitine. Eur J Pharmacol 342:183-191
  • Seitz U, Ameri A (1998) Different effects on [3H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Biochem Pharmacol 55:883-8
  • Ameri A (1998) Structure-dependent inhibitory action of the Aconitum alkaloids 14-benzoyltalitasamine and talitasamine in rat hippocampal slices. Naunyn-Schmiedeberg’s Arch Pharmacol 357:585-92
  • Ameri A (1998) The effects of Aconitum alkaloids on the central nervous system. Progr Neurobiol 56:211-235
  • Ameri A, Seitz U (1998) Effects of mesaconitine on [3H]noradrenaline uptake and neuronal excitability in rat hippocampus. Exp Brain Res 121:451-6
  • Ameri A (1998) Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol 125:461-8
  • Gutser UT, Gleitz J (1998) The alkaloid 6-benzoylheteratisine inhibits voltage-gated Na+ channels in rat brain synaptosomes. Neuropharmacology 37:1139-46
  • Friese J, Gleitz J (1998), Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-a-benzoate to receptor site 2 of voltage-gated Na+ channels. Planta Med 64:458-9
  • Heubach JF, Schüle A (1998) Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med 64:22-6
  • Niebch B, Büchele B, Blome J, Grieb S, Brandt G, Kampa P, Raffel HH, Locher M, Borbe HO, Nubert I, Fleischhauer I (1997) Enanatioselective high-performance liquid chromatography assay of (+)R- and (-)S-a-lipoic acid in human plasma. Chirality 9:32-6
  • Gleitz J, Beile A, Wilkens P, Ameri A, Peters T (1997) Antithrombotic action of the kava pyrone (+)-kavain prepared from Piper methysticum on human platelets. Planta Med 63:27-30
  • Magura EI, Kopanitsa MV, Gleitz J, Peters T, Krishtal OA (1997) Kava extract ingredients, (+)-methysticin and (±)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Neuroscience 81:345-51
  • Friese J, Gleitz J, Gutser UT, Heubach JF, Matthiesen T, Wilffert B, Selve N (1997) Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties. Eur J Pharmacol 337:165-74
  • Teufel-Mayer R, Gleitz J (1997) Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors. Pharmacopsychiatry 30 (Suppl 2):113-6
  • Seitz U, Schüle A, Gleitz J (1997) [3H]-Monoamine uptake inhibition properties of kava pyrones. Planta Med 63:548-9
  • Ameri A (1997) Inhibition of rat hippocampal excitability by the plant alkaloid 3-acetylaconitine mediated by interaction with voltage-dependent sodium channels. Naunyn-Schmiedeberg’s Arch Pharmacol 355:273-80 
  • Ameri A (1997) Electrophysiological actions of the plant alkaloid 6-benzoylheteratisine in rat hippocampal slices. Naunyn-Schmiedeberg’s Arch Pharmacol 355:538-44
  • Ameri A, Peters T (1997) Calcium-dependent, sustained enhancement of excitability during washout of aconitine in rat hippocampal slices. Exp Brain Res 114:518-24
  • Ameri A, Gleitz J, Peters T (1997) Bicuculline-induced epileptiform activity in rat hippocampal slices: suppression by Aconitum alkaloids. Planta Med 63:228-32
  • Ameri A (1997) Effects of the alkaloids 6-benzoylheteratisine and heteratisine on neuronal activity in rat hippocampal slices. Neuropharmacology 36:1039-46
  • Heubach JF, Heer F, Wilhelm D, Peters T (1997) 6-Benzoylheteratisine - a class-I antiarrhythmic substance from Aconitum tanguticum (Maxim.) Stapf. Phytomedicine 4:109-15
  • Syrovets T, Thillet J, Chapman MJ, Simmet Th (1997) Lipoprotein(a) is a potent chemoattractant for human peripheral monocytes. Blood 90:2027-36
  • Syrovets T, Tippler B, Rieks M, Simmet Th (1997) Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway. Blood 89:4574-83
  • Gleitz J, Peters M (1997) Influence of extracellular K+ concentration on the time-course of Na+/K+-ATPase inhibition by cardiac glycosides with fast and low binding kinetics. Eur J Pharmacol 335:89-97
  • Ameri A (1997) Inhibition of rat hippocampal excitability by the Aconitum alkaloid 1-benzoylnapelline, but not by napelline. Eur J Pharmacol 335:145-52
  • Ameri A (1997) Structure-dependent differences in the effects of the Aconitum alkaloids lappaconitine, N-desacetyllappaconitine and lappaconidine in rat hippocampal slices. Brain Res 769:36-43
  • Seitz U, Ameri A, Pelzer H, Gleitz J, Peters T (1997) Relaxation of evoked contractile activity of isolated guinea-pig iIeum by (±)-kavain. Planta Med 63:303-6
  • Friese J, Gleitz J, Gutser UT, Heubach JF, Matthiesen T, Wilffert B, Selve N (1997) Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties. Eur J Pharmacol 337:165-74
  • Belsner K, Büchele B (1996) Fluorescence detection of cardenolides in reversed-phase high-performance liquid chromatography after post-column derivatization. J Chromatogr B 682:85-107
  • Gleitz J, Tosch C, Beile A, Peters T (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35:1743-52
  • Gleitz J, Beile A, Wilkens P, Ameri A, Peters T (1996) Antithrombotic action of the kava pyrone (+)-kavain prepared from Piper methysticum on human platelets. Planta Med 63:27-30
  • Ameri A, Metzmeier P, Peters T (1996) Frequency-dependent inhibition of neuronal activity by lappaconitine in normal and epileptic hippocampal slices. Br J Pharmacol 118:577-84
  • Gleitz J, Tosch C, Peters T (1996) Continuous enzyme-linked fluorometric detection of L(+)-lactate released from rat brain vesicles under anoxic conditions. J Neurosci Meth 67:97-102 
  • Ameri A, Gleitz J, Peters T (1996) Aconitine inhibits epileptiform activity in rat hippocampal slices. Naunyn-Schmiedeberg’s Arch Pharmacol 354:80-5
  • Ameri A (1996) Age-dependent differences in sensitivity to aconitine of rat hippocampal slices. Neurosci Lett 216:13-6
  • Ameri A, Shi Q, Aschoff J, Peters T (1996) Electrophysiological effects of aconitine in rat hippocampal slices. Neuropharmacology 35:13-22
  • Gleitz J, Friese J, Beile A, Ameri A, Peters T (1996) Anticonvulsive action of (±)-kavain estimated from its properties on stimulated symptosomes and Na+ channel receptor sites. Eur J Pharmacol 315:89-97
  • Ameri A, Gleitz J, Peters T (1996) Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids. Brain Res 738:154-57
  • Gleitz J, Gottner N, Ameri A, Peters T (1996) Kavain inhibits non-stereospecifically veratridine-activated Na+ channels. Planta Med 62:580-1
  • Gleitz J, Beile A, Peters T (1996) (±)-Kavain inhibits the veratridine- and KCl-induced increase in intracellular Ca2+ and glutamate-release of rat cerebrocortical synaptosomes. Neuropharmacology 35:179-86
  • Kleiser B, Diepers M, Geiger S, Horn E, Gleitz J, Peters T, Kornhuber HH (1995) Combined therapy with flunarizine and memantine of experimental intracerebral hematomas in rats. Neurol Psychiat Brain Res 3:219-24
  • Lauterwein M, Oethinger M, Belsner K, Peters T, Marre R (1995) In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganismus. Antimicrob Agents Chem 39:2541-43
  • Gleitz J, Beile A, Peters T (1995) (±)-Kavain inhibits veratridine-activated voltage-dependent Na+-channels in synaptosomes prepared from rat cerebral cortex. Neuropharmacology 34:1133-8
  • Gleitz J, Peters T (1995) Pharmakologische Bedeutung magensaftresistenter Formulierungen von Knoblauchpulver-Präparaten. Med Welt 46:458-60